RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-154
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
PCR; dual-luciferase reporter assay etc.
Target
DDK2
Pathway
WNT SIGNALING PATHWAY
PubMed ID
Title
MiR-154 directly Suppresses DKK2 to Activate Wnt Signaling Pathway and Enhance Activation of Cardiac Fibroblasts
Year
2016
Function
Targeting of DKK2 by miR-154 leads to upregulation of b-catenin expression and activation of the classical WNT signaling pathway and cardiac fibroblasts (CFs).